hrp0082p3-d1-767 | Fat Metabolism & Obesity | ESPE2014

Prevalence Metabolic Syndrome and Its Components Among Children with Obesity

Latyshev Oleg , Kiseleva Elena , Okminyan Goar , Samsonova Lubov , Kolomina Irina

Background and aims: To study the prevalence of metabolic syndrome and its components (impaired fasting and after overload glucose, type 2 diabetes mellitus, low cholesterol HDL, and high triglycerides) in children with obesity.Methods: This research includes 550 (65.8% boys) children, recruited from Pediatric Endocrinology Department, with abdominal obesity. We measured BMI, waist circumference, blood pressure with standard instrumentation and glucose (...

hrp0082p3-d3-940 | Puberty and Neuroendocrinology (1) | ESPE2014

Inhibin B in the Boys with Constitutional Delay of Puberty: Relationship with Gonadotropins, Testosterone, and Anti-Müllerian Factor

Latyshev Oleg , Kiseleva Elena , Okminyan Goar , Samsonova Lubov

Objective: The aim of this study were to investigate the level of inhibin B and its relationship with testosterone, anti-Müllerian factor, basal, and GnRH-stimulated gonadotropin hormones (LH and FSH) concentration in boys with constitutional delay of puberty.Material and methods: In the study were included 15 boys (mean age 14.5±1.6 years) in Tanner stages 1–2. The investigation consists of genital examination with prader orchidometer, de...

hrp0084p3-796 | DSD | ESPE2015

Tumours of Gonads in Patients with Disorders of Sex Development – 46,XY Gonadal Dysgenesis

Latyshev Oleg , Samsonova Lubov , Okulov Alexey , Kiseleva Elena , Okmynuan Guar

Background: Disorders of sex development, especially with Y chromosome material, are the main factor of an increased risk of gonadal tumour. The main idea of this study was to investigate the prevalence of gonad tumours in patients with 46,XY gonadal dysgenesis.Methods: This study included 9 patients with 46,XY gonadal dysgenesis: seven patients with partial and two with total gonadal dysgenesis. Among nine patients there were two patients with Frasier s...

hrp0097p2-316 | Late Breaking | ESPE2023

Family case of constitutional delay of puberty

Latyshev Oleg , Okminyan Goar , Kiseleva Elena , Romaykina Daria , Samsonova Lubov

Introduction: One of the strategies of searching the genetic causes of CDGP is analysing the genes responsible for hypogonadotropic hypogonadism (HH).Objective: To investigate the role of the HS6ST1 gene in development CDGP.Materials and Methods: Two patients - height and BMI SDS, bone age, genitometric parameters, basal hormones, GnRH analogue test, hCG test, olfactometry, brain-M...

hrp0095p1-37 | Diabetes and Insulin | ESPE2022

The role of insulin resistance and pancreatic β-cell dysfunction in the development of prediabetes in obese adolescents

MinkovaNadezda , Latyshev Oleg , Kiseleva Elena , Okminyan Goar , Romaykina Daria , Samsonova Lubov

Background: The pathophysiology of type 2 diabetes mellitus (T2DM) is based on defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Young people have a more aggressive course of the disease. However, the impact and sequence of pathological mechanisms involved in the development of T2DM in adolescents hasn’t been established. Diagnosis of the prediabetes in time can be u...

hrp0095p2-112 | Fat, Metabolism and Obesity | ESPE2022

Prediabetes in Obesity Adolescents: Frequency, Structure, Relationship with Body Mass Index

Minkova Nadezda , Latyshev Oleg , Kiseleva Elena , Okminyan Goar , Romaykina Daria , Samsonova Lubov

Background: The increased prevalence of youth obesity has led to raised youth-onset type 2 diabetes mellitus (T2DM), as well as the intermediate condition of prediabetes. Diagnosis of prediabetes can help preventing of the development of T2DM.Aims: to study the frequency, clinical laboratory diagnostics and relationship of prediabetes with SDS BMI in obese adolescents.Materials: Th...

hrp0095p2-258 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Comparative characterization of hypogonadotropic hypogonadism and constitutional delayed puberty in girls

Kabolova Kseniya , Latyshev Oleg , Samsonova Lubov , Romaykina Daria , Okminyan Goar , Kiseleva Elena

Objective of the research: To compare clinical laboratory and genitometric parameters in girls with hypogonadotropic hypogonadism (HH) and constitutional delayed puberty (CDP).Materials and Methods: 23 female patients with delayed puberty are included in the study.Inclusion criteria: Absence of secondary sexual characteristics at age ≥13 years or absence of menarche at age ≥1...

hrp0092p3-224 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Clinical and Laboratory Characteristics of Different Various Types of Gonadal Dysgenesis in Girls with Hypergonadotropic Hypogonadism

Kabolova Kseniya , Oleg Latyshev , Lubov Samsonova , Elena Kiseleva , Goar Okminyan , Kristina Kokoreva , Elvira Kasatkina

Objective: to evaluate clinical and laboratory characteristics of various types of gonadal dysgenesis in girls with hypergonadotropic hypogonadism.Methods: 17 girls with hypergonadotropic hypogonadism (13.9±3.72) were examined. Inclusion criteria: characteristics of delayed puberty, no disorders of sex development, presence of müllerian duct derivatives, high levels of gonadotrophins. Tanner stage, antropometri...

hrp0092p3-242 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Clinical and Laboratory Characteristics of Patients with Different Variants of Gonadal Dysgenesis

Latyshev Oleg , Sannikova Ekaterina , Samsonova Lubov , Kiseleva Elena , Okminyan Goar , Kasatkina Elvira , Volodko Elena , Dondup Olga

Objective: To study clinical and laboratory characteristics of patients with disorders of sex development (DSD) 45,X/46,XY and 46,XY, partial gonadal dysgenesis.Subjects and Methods: It was included 27 patients with disorders of gonadal dysgenesis at birth to 9 years, which were divided into groups based on cytogenetic survey – DSD 46,XY, partial gonadal dysgenesis (n=10) and DSD 45,X/46,XY (n&...

hrp0086p2-p403 | Gonads & DSD P2 | ESPE2016

Endocrine Risk Factors of Testicular Cancer of Children and Teenagers with Testicular Microlithiasis

Kabolova Kseniya , Latyshev Oleg , Samsonova Lubov , Kiseleva Elena , Okminyan Goar , Kasatkina Elvira

Objective and hypotheses: To evaluate endocrine risk factors of testicular cancer of children with testicular microlithiasis.Method: Under research were 74 patients with testicular microlithiasis (average 11.41±4.02). Heredity, case history, endocrine diseases, anthropometric indicators, ultrasound of the scrotum were evaluated.Results: At 20 of 74 (27%) children microlithiasis was combined with strong risk factors of testicle...